PKRRATING FOR DUMMIES

pkrrating for Dummies

The interfacial residues are highly conserved amongst eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements display the kinase domains dimerize when PKR binds to activating dsRNAs19. These observations help a model exactly where activating RNA serves as a scaffold to bind a number of PKR monomers, escalating t

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